How to take Iloprost
There are 2 ways to take Iloprost, infusion or nebuliser.
Iloprost is a calcium channel blocker, a medicine used to treat high blood pressure (hypertension) and angina (pain in the heart caused when the blood supply to the heart's muscles is restricted). Calcium channel blockers work by relaxing your artery wall muscles. This widens your arteries and reduces your blood pressure.
Iloprost is a man-made form of a substance called prostacyclin which is produced naturally in the body and improves blood flow in people with severe circulatory problems by reducing clumping of the red cells in the blood, which reduces the tendency of the blood to clot helping to prevent or repair damage to blood vessels.
Iloprost usually starts to work immediately, although it can sometimes take up to six weeks.
If you've been suffering with very cold hands or feet they may feel warmer straight away. Ulcers may begin to improve within a few days.
Iloprost's beneficial effects may carry on for weeks and sometimes even months after the infusion. Usually, iloprost is prescribed if other drugs such as nifedipine haven't worked for you. Your doctor will discuss other treatment options with you if need be.
Iloprost is given through a drip (infusion) into your arm, usually continuously for about six hours a day for 3–5 days in a row in hospital or a clinic. It can sometimes be given continuously over 24 hours. You can also take it via a nebuliser.
The infusion will be started at a low dose and then increased gradually to make sure you can tolerate the higher doses. If you develop side-effects, your dose will generally be reduced again.
The rate at which iloprost is given depends on your weight, but can also be adjusted if you have side-effects.
You will need to stay in hospital for up to three days for treatment and to monitor your response. After this, you should be able to return home and continue taking the medicine.
How long you need to take iloprost for will depend on your condition. You may need to continue taking it, possibly alongside other treatments, until your condition worsens and you need epoprostenol.
Iloprost may not be suitable if:
Information sourced from the NHS, Mayo Clinic and Arthritis Research UK.