In diffuse scleroderma, it is more likely that the whole body will be affected compared with limited systemic sclerosis where part of the body is affected. Common symptoms include fatigue, joint pain, and stiffness.
In this type of scleroderma, systemic scleroderma, the internal organs are affected as well as the skin. The oesophagus, blood vessels, blood pressure and digestive system can all be involved. In some cases there can be potentially serious complications involving the heart, lungs and kidneys.