Systemic sclerosis can be difficult to diagnose as it can develop gradually and can take different forms.

There is no single test or feature which gives a yes/no answer. Instead, the diagnosis is made after looking at the whole person, taking into account their symptoms, physical examination and blood tests. This may involve seeing a specialist – usually a rheumatologist, who is a doctor specialising in joint and connective tissue diseases.

These tests or indicators can include: 

  • ANA (antinuclear antibody) test 
  • Raynaud’s phenomenon  
  • Nailfold Capillaroscopy  
  • Skin biopsy 
  • Modified Rodnan Skin Score 
  • Blood pressure tests 
  • Other blood tests 
  • Gag reflux problems 
  • Biomarkers 
  • X-rays 
  • CT scans 
  • Organ specific tests: including ECG heart test, endoscopy, echocardiogram, pulmonary function tests 

Below Dr John Pauling explains various tests we use to diagnose systemic sclerosis:

The Importance of Very Early Diagnosis

Professor Marco Matucci Cerinic, Scientific Consultant IRCCS Hospital San Raffaele, Milan talks about the importance of very early diagnosis (VEDOSS) in systemic sclerosis at the 2025 Cambridge Conference.

Узнайте больше о системном склерозе

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Недавно диагностированный системный склероз

Answers to questions you might be asking when you have been newly diagnosed
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Лечение системного склероза

Лекарства от склеродермии пока нет. Но лечение направлено на купирование симптомов и ограничение повреждений тканей и органов.
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Вопросы и ответы о склеродермии

Everyone has questions about scleroderma, and here we have compiled some of the most common questions we are asked about scleroderma.