Systemic sclerosis can be difficult to diagnose as it can develop gradually and can take different forms.

There is no single test or feature which gives a yes/no answer. Instead, the diagnosis is made after looking at the whole person, taking into account their symptoms, physical examination and blood tests. This may involve seeing a specialist – usually a rheumatologist, who is a doctor specialising in joint and connective tissue diseases.

These tests or indicators can include: 

  • ANA (antinuclear antibody) test 
  • Raynaud’s phenomenon  
  • Nailfold Capillaroscopy  
  • Skin biopsy 
  • Modified Rodnan Skin Score 
  • Blood pressure tests 
  • Other blood tests 
  • Gag reflux problems 
  • Biomarkers 
  • X-rays 
  • CT scans 
  • Organ specific tests: including ECG heart test, endoscopy, echocardiogram, pulmonary function tests 

Below Dr John Pauling explains various tests we use to diagnose systemic sclerosis:

The Importance of Very Early Diagnosis

Professor Marco Matucci Cerinic, Scientific Consultant IRCCS Hospital San Raffaele, Milan talks about the importance of very early diagnosis (VEDOSS) in systemic sclerosis at the 2025 Cambridge Conference.

Find out more about systemic sclerosis

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Newly diagnosed with Systemic Sclerosis

Answers to questions you might be asking when you have been newly diagnosed
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Systemic Sclerosis treatments

We don’t have a cure yet for scleroderma. But treatment aims to manage your symptoms, and to limit damage to your tissues and organs.
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FAQs about Scleroderma

Everyone has questions about scleroderma, and here we have compiled some of the most common questions we are asked about scleroderma.